Space Hulk
Possibly /tg/s favorite board game, rivaled by a select few such as HeroQuest and Settlers of Catan.
Features two small factions from the 40K universe: Genestealers, a subspecies of Tyranid who tend to infest Space Hulks so they can OM NOM NOM. The other faction is compossed of a Space Marine Terminator squad, who enter these hulks to recover long lost technology and pretty much kill everything they see. The game is fucking hardcore for both sides - Genestealers, because they have no ranged weapons, and Terminators, because they have little mobility, few numbers, and, for all but a select few Terminators, are very vulnerable in close-range combat. (The deficiencies in hand-to-hand can be made up by equipping Terminators with Lightning Claws or the Thunder Hammer and Storm Shield, both added in the Deathwing Expansion.)