Mutant Chronicles

Mutant Chronicles is sci-fantasy setting created by Target Games in 1993. It is best described as Shadowrun IN SPAAACE, although it is set only in Solar System. Also, it borrows some inspiration from W40K. It has megacorporations, cyberware, cyberspace, hueg guns, swords (heck, even chainswords!), shoulderpads, mutants (duh), religious fanatics, demons, magic... And it is pretty grimdark too.

Originally it was only RPG, than came card game (Doomtrooper), wargame (Warzone, similar to Warhammer) and several desktop games. There is even 2008 movie adaptation directed by Simon Hunter, but completely derped… basically they just used the name of the franchise and several characters. But hey, it has Ron Perlman, John Malkovich, Thomas Jane and Sean Pertwee, which is quite awesome if you ask me.