Witch Hunters
Here there be witches and all must die — Creature Feature
Known as the Ordo Hereticus, the Witch Hunters are a branch of the Inquisition dedicated and specialized in hunting down and destroying witches, heretics, and mutants in the name of the Empra but will also kill just about anyone who's an enemy of the Imperium if confronted. Commonly fields Sisters of Battle or Inquisitorial Storm Troopers, though a Witch Hunter Inquisitor Lord may call on the Imperial Guard, Space Marines and even Grey Knights to assist them in battle.
All female Sisters of Battle players rage hard when you call SoBs 'Witch Hunters' or imply that they are the same group. Matt Ward apparently agrees because as of 5E they have been separated again. Fucking Ward. They have a WFB equivalent. Also called, unsurprisingly, Witch Hunters. Both flavors get bitchin' pimp hats and the fantasy counterparts have the only reliable guns in the world.
FUCK YEAH!
So what is heresy?
IF IT AIN'T INVOLVING THE EMPEROR, IT'S ALL HERESY!
This above sentence may seem an overstatement but really it is closer to the truth then you'd think. To the Witch Hunters anything that veers from the Emperor's light is to be found and purged and the purging is usually done in fire.
Unlike the Daemonhunters, Witch Hunters act as more of a police instead of a military force. While the Daemon Hunters search the stars for daemons and the chaos crazies responsible for them with the Grey Knights; Witch Hunters are instead more focused on rooting out heresy from within the Imperium's worlds, finding heretics that have infiltrated the Imperium already and purging any cults they may have formed.
They are the fire and brand Inquisitors which give the Inquisition it's dark reputation and all you heard about them is very true.
Notable Members of the Ordos Hereticus
Lord Inquisitor Fyodor Karamazov
Lazy bastard. Sits on a massive, dreadnought-esque chair and merely points to where the servitor should aim his triple-linked multi-melta. He's a great believer in Just. As. Planned. but the Empy version. Jokingly called Lord Krazypantsoff by several immature (and hilarious) users of /tg/. He's also bald due to an anti-aging cream gone wrong - all the workers for the company (called Dove) were subsequently purged and crucified.
He's named after Fyodor Dostoyevsky, and his famous book The Brothers Karamazov - which is known for its chapter The Grand Inquisitor.
Witch Hunter Tyrus
This guy is so badass that all the motherflippin' ladies get PURGED when he enters the room. He was taken under the care of an inquisitor as a child after a Daemon Prince ripped one of his ears and eyes out for fun before razing the rest of his village. Years later, the same Daemon Prince killed his mentor in battle but Tyrus was able to banish the bastard back to the warp again. His favorite method for finding HERESY is forcing the accused to consume a jug of holy water. If they choke then they are considered heretic and crucified, shot, burned, then he lets a blind butcher loose on them, then they get shot again.
Plus he loathes psykers, even the ones in the Inquisition. So don't ask him if he wants to see your new magic card trick.
Adrastia
Adrastia is a lot like what you'd expect from a Witch Hunter. Suspicious, ruthless, uncompromising and utterly devoted to finding and destroying all things heretical for the Emprah. She has a haughty and cavalier attitude and frequently found herself in conflict with Sergeant Merrick who was convinced she only came to sub-sector Aurelia because she hoped to capture Kyras and net herself a promotion rather than actually giving a crap about the sub-sector's imminent annihilation. She doesn't really bother to confirm or deny his accusations instead telling him to quit bitching at her and get on with his work but when Kyras turns into a gigantic Daemon the option to capture him alive quickly disappears so who knows. Her personality is somewhat grumpy and harsh having very little time for anyone who is not a heretic or pointing her in the direction of one (then again being kind of a buzzkill is pretty normal for Inquisitors who are not Amberley Vail so we can't really fault Adrastia for that). She's also a radical Inquisitor, more specifically a Xanthian, given that she has no qualms using chaos artifacts against the enemy, like a Daemon blade you find along the way.