Witch Hunters
Here there be witches and all must die — Creature Feature
Known as the Ordo Hereticus, the Witch Hunters are a branch of the Inquisition dedicated and specialized in hunting down and destroying witches, heretics, and mutants in the name of the Empra but will also kill just about anyone who's an enemy of the Imperium if confronted. Commonly fields Sisters of Battle or Inquisitorial Storm Troopers, though a Witch Hunter Inquisitor Lord may call on the Imperial Guard, Space Marines and even Grey Knights to assist them in battle.
All female Sisters of Battle players rage hard when you call SoBs 'Witch Hunters' or imply that they are the same group. Matt Ward apparently agrees because as of 5E they have been separated again. Fucking Ward. They have a WFB equivalent. Also called, unsurprisingly, Witch Hunters. Both flavors get bitchin' pimp hats and the fantasy counterparts have the only reliable guns in the world.
FUCK YEAH!
So what is heresy?
IF IT AIN'T INVOLVING THE EMPEROR, IT'S ALL HERESY!
This above sentence may seem an overstatement but really it is closer to the truth then you'd think. To the Witch Hunters anything that veers from the Emperor's light is to be found and purged and the purging is usually done in fire.
They won't involve themselves with policing minor nuisances (like a random Imperial citizen having disloyal thoughts) but you shouldn't go mentioning it to them unless you want a bullet between the eyes. They focus on bigger more damaging threats like chaos cults, corrupt planetary officials and rogue psykers.
They are the fire and brand Inquisitors which give the Inquisition it's dark reputation and all you heard about them is very true.
Notable Members of the Ordos Hereticus
Lord Inquisitor Fyodor Karamazov
Lazy bastard. Sits on a massive, dreadnought-esque chair and merely points to where the servitor should aim his triple-linked multi-melta. He's a great believer in Just. As. Planned. but the Empy version. He's known in WH40K fluff for being the only inquisitor, and probably the only person in the entire Imperium, in history to give the Ecclesiarchy the big middle finger and get away with it. Space Wolves opened fire on the Ecclesiarchy with no consequences. The Space Wolves aren't a single person, now are they? Jokingly called Lord Krazypantsoff by several immature (and hilarious) users of /tg/.
He's also bald due to an anti-aging cream gone wrong - all the workers for the company (called Dove) were subsequently purged and crucified.
He's named after Fyodor Dostoyevsky, and his famous book The Brothers Karamazov - which is known for its chapter The Grand Inquisitor.
Witch Hunter Tyrus
This guy is so badass that all the motherflippin' ladies get PURGED when he enters the room. He was taken under the care of an inquisitor as a child after a Daemon Prince ripped one of his ears and eyes out for fun before razing the rest of his village. Years later, the same Daemon Prince killed his mentor in battle but Tyrus was able to banish the bastard back to the warp again. His favorite method for finding HERESY is forcing the accused to consume a jug of holy water. If they choke then they are considered heretic and crucified, shot, burned, then he lets a blind butcher loose on them, then they get shot again.
Plus he loathes psykers, even the ones in the Inquisition. So don't ask him if he wants to see your new magic card trick.